一项得克萨斯州技术研究发现,阿尔茨海默氏氏血脑屏障在使用氨基甲状腺斑块的阿尔茨海默氏大鼠中基本完好无损,对先前的假设提出了挑战。 A Texas Tech study finds the blood-brain barrier remains mostly intact in Alzheimer’s mice with amyloid plaques, challenging previous assumptions.

德克萨斯州科技大学的研究质疑阿尔茨海默氏症血脑屏障泄漏的想法, 发现Tg2576鼠体内有氨基甲状腺斑块的血-脑屏障基本完好无损。 A Texas Tech University study challenges the idea that the blood-brain barrier leaks in Alzheimer’s, finding it largely intact in Tg2576 mice with amyloid plaques. 使用先进的跟踪方法，研究人员检测到进入大脑的示踪剂很少，这表明尽管斑块堆积，屏障功能仍然稳定。 Using advanced tracking methods, researchers detected minimal tracer entry into the brain, suggesting barrier function remains stable despite plaque buildup. 调查结果对阿尔茨海默氏症药物提供情况的假设提出疑问,并强调需要更好的模型和进一步研究,包括测试林业发展局核准的抗体是否具有潜在的BBB效应。 The findings question assumptions about drug delivery in Alzheimer’s and highlight the need for better models and further research, including testing FDA-approved antibodies for potential BBB effects.