一项研究发现,聚氧素抗生素通过超载其外层,使休眠的抗生素不受影响,只能杀死生长中的细菌。 Polymyxin antibiotics kill only growing bacteria by overloading their outer layer, leaving dormant ones untouched, a study finds.

一项新的研究表明,用于抗药性细菌的聚菌素抗生素只能通过诱骗细菌过度生产其保护外层来杀死活性生长的细菌,从而导致结构崩溃。 A new study reveals that polymyxin antibiotics, used against drug-resistant bacteria, only kill actively growing bacteria by tricking them into overproducing their protective outer layer, causing structural collapse. 停止生产这种盔甲的多曼特细菌 仍然不受影响 Dormant bacteria, which stop producing this armor, remain unaffected. 研究人员利用高分辨率成像实时观察这个过程,表明重新引进象糖这样的养分可以唤醒休眠细胞,在延迟15分钟后使他们再次变得脆弱。 Researchers used high-resolution imaging to observe this process in real time, showing that reintroducing nutrients like sugar can wake dormant cells, making them vulnerable again after a 15-minute delay. 这些结果发表在《自然微生物学》中,质疑关于这些抗生素在所有细菌状态上都起作用的信念,并建议将这些抗生素与刺激细菌活动的物剂结合起来,可以改进对持久性感染的治疗。 The findings, published in Nature Microbiology, challenge the belief that these antibiotics work on all bacterial states and suggest combining them with agents that stimulate bacterial activity could improve treatment for persistent infections.