在实验室模型中通过启动SORD传播的糖饮料燃料直肠癌,SORD是潜在治疗目标。 Sugary drinks fuel colorectal cancer spread in lab models by activating SORD, a target for potential therapies.

德克萨斯大学MD Anderson癌症中心的一项新研究,发表于2025年9月19日,《自然代谢》,《自然代谢》,发现糖饮料燃料中的葡萄糖-纤维糖混合物通过激活酶SORD(SORD),在临床前型高级直肠癌中发生转移,引发葡萄糖代谢,并引发与癌症蔓延相关的胆固醇途径。 A new study from the University of Texas MD Anderson Cancer Center, published September 19, 2025, in Nature Metabolism, finds that the glucose-fructose mix in sugary drinks fuels metastasis in advanced colorectal cancer in preclinical models by activating the enzyme SORD, which boosts glucose metabolism and triggers a cholesterol-related pathway linked to cancer spread. 阻断SORD,即使食糖摄取量也减少了转移,指出潜在的治疗目标。 Blocking SORD reduced metastasis even with sugar intake, pointing to a potential therapeutic target. 研究进一步证明饮食影响癌症的进展超出肥胖, 表明减少含糖饮料的消费, 准SORD, 或重新使用他类药物可能有助于限制转移. The research adds to evidence that diet influences cancer progression beyond obesity, suggesting that reducing sugary drink consumption, targeting SORD, or repurposing statins may help limit metastasis. 调查结果强调了在癌症护理中饮食考虑的重要性,特别是鉴于许多营养补充品和果汁中推荐给病人的食糖含量较高。 The findings underscore the importance of dietary considerations in cancer care, especially given high sugar levels in many nutritional supplements and juices recommended for patients. 需要进一步的临床研究来确认这些结果。 Further clinical studies are needed to confirm these results.