一项研究发现与肥胖者更好的代谢健康相联系的遗传变异,帮助确定亚型和预测并发症。 A study finds genetic variants linked to better metabolic health in obese people, helping identify subtypes and predict complications.

由西奈山和哥本哈根大学牵头的一项新研究于2025年9月15日发表在《自然医学》上。 这项研究查明了与健康代谢特征相联系的遗传变异物,尽管身体脂肪高,说明为什么一些肥胖者避免患糖尿病和心脏病等疾病。 A new study led by Mount Sinai and the University of Copenhagen, published in Nature Medicine on September 15, 2025, identifies genetic variants linked to healthier metabolic profiles despite high body fat, explaining why some obese individuals avoid conditions like diabetes and heart disease. 研究人员分析了来自450 000多名欧洲血统人口的数据,发现有205个基因组区域与肥胖有关,但新陈代谢健康较好,从而能够得出对肥胖子型进行分类的遗传风险评分。 Analyzing data from over 450,000 people of European ancestry, researchers found 205 genome regions associated with obesity but better metabolic health, enabling the creation of a genetic risk score to classify obesity subtypes. 这将有助于医生预测并发症,发展个性化治疗,尽管今后的研究将侧重于不同人群。 This could help doctors predict complications and develop personalized treatments, though future research will focus on diverse populations.