科学家发现一种蛋白质 让骨癌抵抗免疫疗法 带来新的治疗希望 Scientists find a protein that makes bone cancers resist immunotherapy, offering new treatment hopes.

研究人员已经发现一种蛋白质,DKK1,由骨质转移产生,重新编程免疫细胞,使骨骼中的癌症抗免疫治疗。 Researchers have identified a protein, DKK1, produced by bone metastases that reprograms immune cells, making cancers in bones resistant to immunotherapy. 这一发现表明,封锁DKK1可以提高免疫疗法对骨肿瘤的效用,而骨肿瘤目前治疗选择有限。 This discovery suggests that blocking DKK1 could improve immunotherapy's effectiveness against bone tumors, which currently have limited treatment options. 此外,CHI3L3可充当生物标志,专门为高免疫力患者提供专门治疗。 Additionally, CHI3L3 may serve as a biomarker to tailor treatments for patients with high immune resistance.