研究表明,CAR T细胞的信号类型不同,在癌症治疗方面可提供各种好处。 Study reveals CAR T cells with different signaling types offer varying benefits in cancer treatment.

最近的一项科学进步研究揭示了在癌症免疫疗法中使用的不同类型CAR T细胞如何瞄准和摧毁癌症细胞。 A recent study in Science Advances reveals how different types of CAR T cells, used in cancer immunotherapy, target and destroy cancer cells. 研究者发现,带有CD28的CAR T细胞表示迅速杀死癌症细胞,而带有4-1BB细胞的CAR T细胞则表示长期消除癌症细胞。 Researchers found that CAR T cells with CD28.ζ signaling kill cancer cells quickly, while those with 4-1BB.ζ signaling maintain long-term cancer cell elimination. 这一发现有助于为更广泛的癌症,包括具有挑战性的固态肿瘤发展CAR治疗。 This discovery could help in developing CAR T therapies for a wider range of cancers, including challenging solid tumors.