研究人员发现Staphylococccus Aureus用IL-10拆除抗体,阻碍疫苗的功效。 Researchers found Staphylococcus aureus deactivates antibodies with IL-10, blocking vaccine effectiveness.

圣地亚哥哥伦比亚大学的研究人员发现,作为皮肤感染常见病因的Staphylococcus Aureus人体疫苗在临床试验中失败的原因。 Researchers at UC San Diego have discovered why human vaccines for Staphylococcus aureus, a common cause of skin infections, have failed in clinical trials. 细菌产生过量的内红素-10(IL-10),这种蛋白质可以解除抗体的功能,防止它们杀死细菌。 The bacteria produce an excess of interleukin-10 (IL-10), a protein that deactivates antibodies, preventing them from killing the bacteria. 通过在免疫期间封锁IL-10,小鼠恢复了疫苗的功效,为今后的人类疫苗开发提供了潜力。 By blocking IL-10 during immunization, vaccine efficacy was restored in mice, offering potential for future human vaccine development.