研究人员识别了导致阿尔茨海默氏病恶化的免疫细胞,并找到针对这些细胞的现有药物。 Researchers identify immune cells that worsen Alzheimer's and find existing drugs to target them.

克利夫兰临床基因组中心的研究人员发现,被称为微小lia的免疫细胞可以通过引起炎症而使阿尔茨海默氏病恶化。 Researchers at the Cleveland Clinic Genome Center found that immune cells called microglia can worsen Alzheimer's disease by causing inflammation. 该研究确定了三种具有独特遗传特征的有害小胶质细胞亚型，并使用基于网络的方法找到 FDA 批准的药物，如酮咯酸，这些药物可以重新用于靶向这些有害细胞，而不会影响健康的细胞。 The study identified three harmful microglia subtypes with unique genetic signatures and used a network-based approach to find FDA-approved drugs, like Ketorolac, that could be repurposed to target these harmful cells without affecting healthy ones. 这种发现可能导致对阿尔茨海默氏病的新治疗。 This discovery could lead to new treatments for Alzheimer's disease.