研究人员发现了OpgH蛋白在维持细菌形状方面的关键作用，以及它作为致病细菌抗生素靶标的潜力。 Researchers discovered the critical role of OpgH protein in maintaining bacterial shape and its potential as an antibiotic target in disease-causing bacteria.

约翰·霍普金斯大学医学院的研究人员发现，OpgH蛋白在维持细菌形状方面起着关键作用，特别是在淡水湖泊和土壤细菌中。 Researchers at Johns Hopkins Medicine discovered the critical role of OpgH protein in maintaining bacterial shape, especially in freshwater lake and soil bacteria. OpgH的丢失会损害细胞包膜，导致细胞死亡。 The loss of OpgH compromises the cell envelope, leading to cell death. OpgH 产生渗透调节的周质葡聚糖 （OPG），即填充保护细胞膜空间的糖分子。 OpgH generates osmoregulated periplasmic glucans (OPGs), sugar molecules filling the protective cell envelope's spaces. 了解革兰氏阴性菌中的这些糖分子可能有助于开发针对具有OPGs的致病细菌的新药，如布鲁氏菌、假单胞菌、沙门氏菌和大肠杆菌。 Understanding these sugar molecules in gram-negative bacteria could aid in developing new drugs targeting disease-causing bacteria with OPGs, such as Brucella, Pseudomonas, Salmonella, and E. coli. 产生或修饰这些糖分子的蛋白质对细菌的生存至关重要，可能使它们成为抗生素的合适靶标。 The proteins that create or modify these sugar molecules are essential to bacterial survival, potentially making them suitable targets for antibiotics.