15% 的阿尔茨海默病病例与 APOE4 纯合子有关。 15% of Alzheimer's cases linked to APOE4 homozygotes.
研究人员发现,阿尔茨海默病的一种独特遗传形式与拥有两个 APOE4 基因拷贝(APOE4 纯合子)有关,这种疾病影响了 95% 的 65 岁以上人群。 Researchers discovered a distinct genetic form of Alzheimer's disease linked to having two copies of the APOE4 gene (APOE4 homozygotes), affecting 95% of individuals over 65. 这种类型的疾病比其他类型的疾病出现症状更早,可能占阿尔茨海默病病例的 15%。 This form, which causes earlier symptoms than others, may account for 15% of Alzheimer's cases. 该研究结果基于来自 10,000 多人和 3,000 名脑捐赠者的数据,表明拥有两个 APOE4 拷贝可能是一种新的遗传疾病,需要专门的治疗和预防策略。 The findings, based on data from over 10,000 people and 3,000 brain donors, suggest that having two APOE4 copies could be a new genetic form of the disease, requiring specialized treatment and prevention strategies.